Edwige Lorthiois : rechercher sur Z-Library

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1

Small-molecule factor D inhibitors targeting the alternative complement pathway

Maibaum, Jürgen, Liao, Sha-Mei, Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand

Journal:

Nature Chemical Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2016

2

ChemInform Abstract: β-Glycosidase Inhibitors Mimicking the Pyranoside Boat Conformation.

Edwige Lorthiois, Muthuppalaniappan Meyyappan, Andrea Vasella

Journal:

Année:

2001

Fichier:

PDF, 32 KB

2001

3

Spiroquinazolinones as Novel, Potent, and Selective PDE7 Inhibitors. Part 1.

Edwige Lorthiois, et al. et al.

Journal:

Année:

2004

Fichier:

PDF, 20 KB

2004

4

Isoquinuclidine Mimics of β-D-Glucopyranosides: Differences and Similarities in the Mechanism of Action of some β-D-Glucosidases and a β-D-Mannosidase

Matthias Böhm, Edwige Lorthiois, Muthuppalaniappan Meyyappan, Andrea Vasella

Journal:

Helvetica Chimica Acta

Année:

2003

Langue:

english

Fichier:

PDF, 276 KB

english, 2003

5

Synthesis and Evaluation as Glycosidase Inhibitors of Isoquinuclidines Mimicking a Distorted β-Mannopyranoside

Matthias Böhm, Edwige Lorthiois, Muthuppalaniappan Meyyappan, Andrea Vasella

Journal:

Helvetica Chimica Acta

Année:

2003

Langue:

english

Fichier:

PDF, 444 KB

english, 2003

6

Zinca-en-allene cyclization synthesis of substituted tetrahydrofurans

Edwige Lorthiois, Ilane Marek, Christophe Meyer, Jean-F. Normant

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 181 KB

english, 1995

7

A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate

Ulrich Hassiepen, Ulf Eidhoff, Gabriele Meder, Jean-Francois Bulber, Andreas Hein, Ursula Bodendorf, Edwige Lorthiois, Bruno Martoglio

Journal:

Analytical Biochemistry

Année:

2007

Langue:

english

Fichier:

PDF, 209 KB

english, 2007

8

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel-Kader Mafroud, Frederique Royer, Roger Wrigglesworth, Jennifer Schellhaas, Mark Barvian,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 311 KB

english, 2004

9

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois, Patrick Bernardelli, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Lamia Heuze, François Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magal

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 272 KB

english, 2004

10

Resolution of trans-3-aminocyclohexanol

Patrick Bernardelli, Michael Bladon, Edwige Lorthiois, Ajith C Manage, Fabrice Vergne, Roger Wrigglesworth

Journal:

Tetrahedron: Asymmetry

Année:

2004

Langue:

english

Fichier:

PDF, 282 KB

english, 2004

11

Intermolecular carbolithiation of silylated enynes

Edwige Lorthiois, Ilane Marek, Christophe Meyer, Jean F. Normant

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 167 KB

english, 1996

12

Intramolecular carbolithiation of silylated enynes

Edwige Lorthiois, Ilane Marek, Jean F. Normant

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 111 KB

english, 1996

13

Zinca-ene-allene and zinc-enolate cyclization. Towards the synthesis of polysubstituted pyrrolidines

Edwige Lorthiois, Ilane Marek, Jean-F. Normant

Journal:

Tetrahedron Letters

Année:

1997

Langue:

english

Fichier:

PDF, 207 KB

english, 1997

14

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Nga Pham, Pierre Ducrot, François Moreau, Moulay Idrissi, Anita Tertre, Bernadette B

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 301 KB

english, 2004

15

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel-Kader Mafroud, Pierre Ducrot, Roger Wrigglesworth, Françoise Berlioz-Seux, Francis Coleon

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 308 KB

english, 2004

16

Diastereoselective and Enantioselective Intramolecular Amino−Zinc−Enolate Carbometalation Reactions. A New Polysubstituted Pyrrolidines Synthesis

Lorthiois, Edwige, Marek, Ilane, Normant, Jean F.

Journal:

Journal of Organic Chemistry

Année:

1998

Fichier:

PDF, 3.28 MB

1998

17

The Discovery of Novel Potent trans -3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

Lorthiois, Edwige, Breitenstein, Werner, Cumin, Frederic, Ehrhardt, Claus, Francotte, Eric, Jacoby, Edgar, Ostermann, Nils, Sellner, Holger, Kosaka, Takatoshi, Webb, Randy L., Rigel, Dean F., Hassiepe

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2013

18

Amino Zinc Enolate Carbocyclization Reactions. New Access to Polysubstituted Piperidine Derivatives

Lorthiois, Edwige, Marek, Ilane, Normant, Jean F.

Journal:

Journal of Organic Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 158 KB

english, 1998

19

β-Glycosidase inhibitors mimicking the pyranoside boat conformation

Lorthiois, Edwige, Meyyappan, Muthuppalaniappan, Vasella, Andrea

Journal:

Chemical Communications

Année:

2000

Langue:

english

Fichier:

PDF, 66 KB

english, 2000

20

trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: Prime site exploration using an amino linker

Lorthiois, Edwige, Cumin, Frederic, Ehrhardt, Claus, Kosaka, Takatoshi, Sellner, Holger, Ostermann, Nils, Francotte, Eric, Wagner, Trixie, Maibaum, Jürgen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 885 KB

english, 2015

21

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker

Sellner, Holger, Cottens, Sylvain, Cumin, Frédéric, Ehrhardt, Claus, Kosaka, Takatoshi, Lorthiois, Edwige, Ostermann, Nils, Webb, Randy L., Rigel, Dean F., Wagner, Trixie, Maibaum, Jürgen

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2015

22

Discovery of highly potent and selective small-molecule reversible Factor D inhibitors demonstrating alternative complement pathway inhibition in vivo

Lorthiois, Edwige, Anderson, Karen, Vulpetti, Anna, Rogel, Olivier, Cumin, Frederic, Ostermann, Nils, Steinbacher, Stefan, Mac Sweeney, Aengus, Delgado, Omar, Liao, Sha-Mei, Randl, Stefan, Rüdisser, S

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 2.52 MB

english, 2017

23

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D

Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Yoon, Taeyoung, Mac Sweeney, Aengus, Cumin, Frederic, Lorthiois, Edwige, Rüdisser, Simon, Erbel, Paul, Maibaum, Jürgen

Journal:

ACS Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 856 KB

english, 2018

24

Structure-based design and pre-clinical characterization of selective and orally bioavailable Factor XIa inhibitors: Demonstrating the power of an integrated S1 protease family approach.

Lorthiois, Edwige, Roache, James, Barnes-Seeman, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri G., Schiering, Nikolaus, Weihofen, Wilhelm A.,

Journal:

Journal of Medicinal Chemistry

Année:

2020

Fichier:

PDF, 1.75 MB

2020